•  HSN's Complex Formula: Diosmin + Hesperidin + Vitamin C.
•  450mg of Diosmin per capsule - Micronised presentation for maximum nutritional relevance.
•  Hesperidin and Vitamin C from natural plant sources - Extracted from fruits.
•  Enriched composition, free from unnecessary additives - 0% aesthetic ingredients.
•  High concentration | Carefully selected raw materials | The best and most complete Diosmin.

Diosmin Complex 450mg by HSN - Discover it!

Diosmin Complex 450mg from EssentialSeries is a food supplement developed using the best form of Diosmin: micronised, alongside acerola and bitter orange extracts to benefit from their Vitamin C and Hesperidin content, respectively.

The complex formula is designed to harness the benefits of combining two glycosidic flavonoids, Diosmin and Hesperidin, together with Vitamin C, an important and well-known antioxidant in diets worldwide.

HSN's Diosmin Complex is here to take its place in your selection of health-focused food supplements.

The power of Diosmin within your reach

What is Diosmin and why is it of interest?

Diosmin is a natural compound belonging to the flavonoid family, specifically glycosidic flavones. It is predominantly found in citrus fruits, especially in the peel of oranges and lemons. Structurally, it is derived from another flavonoid known as Hesperidin, a component included in the 'Complex' formula you are reading about. Diosmin is obtained by modifying a chemical group in Hesperidin to enhance its solubility and stability. This makes it functionally interesting as it retains the general characteristics of flavonoids with a structure that improves its bioavailability, making it one of the most recognised polyphenols for this feature.

What other elements does HSN's 'Complex' contain?

HSN's formula combines Diosmin with Vitamin C and Hesperidin.

Vitamin C, or ascorbic acid, is a water-soluble vitamin primarily found in citrus fruits (in this case, derived from acerola extract). It is an essential nutrient for humans because we cannot synthesise it, so it must be obtained through the diet. It is classified as a 'water-soluble' vitamin, and its functional importance is closely linked to the immune system and cell protection against oxidative agents.

Hesperidin, on the other hand, is a glycosidic flavonoid. It is abundant in citrus fruits such as orange and lemon peels. In fact, the formula's Hesperidin is derived from a bitter orange fruit extract standardised to Hesperidin content. Hesperidin is a key component in the plant matrix of citrus fruits, contributing to their structure and natural defence; and Diosmin is derived from it.

Diosmin + Hesperidin - A winning combo

Diosmin and Hesperidin are closely related, as the former is a derivative of the latter. During the conversion, Hesperidin oxidises its hydroxyl group on the flavonoid's B ring, resulting in a double bond formation in the central ring, transforming Hesperidin (a flavanone) into Diosmin (a flavone). This transformation does not significantly alter the compound's functional properties but enhances its solubility and stability, making it better suited as the 'core element' of the 'Diosmin Complex' formula.

An HSN formula: Free from aesthetic additives

At HSN, we have always focused on formulating supplements that are not only effective but also efficient. Efficiency includes developing powder, capsule, and tablet formulas (as well as some less common formats like liquids) that do not rely on heavy use of additives.

Why?

Because it is unnecessary. Additives serve a specific role in formulas, and while we strive to minimise their presence, sometimes they are unavoidable. For example, Diosmin Complex 450mg contains magnesium stearate, which is the least present ingredient in the entire formula. Its inclusion is necessary because, due to the physical characteristics of plant extract powders, an anti-caking agent is needed to ensure the product remains easy to handle at home.

This is responsible use of additives; what is irresponsible is that some companies, due to lack of knowledge or experience, fill their products with additives, many of which are aesthetic, such as colourants or opacifiers in capsules. These additives are entirely unnecessary for the product's proper maintenance.

Why is Diosmin Micronised?

Micronisation is a mechanical process that reduces the particle size of a compound, such as Diosmin in this case, to create an extremely fine powder. Reducing particle size increases the specific surface area, meaning the total surface area available relative to the compound's mass. This increase in surface area allows greater contact with bodily fluids, facilitating its dissolution. By enhancing solubility, the compound is absorbed more efficiently in the gastrointestinal tract, increasing its bioavailability – the proportion that reaches systemic circulation and is available to exert its nutritional effect. This feature of micronisation is well-documented in scientific literature, as highlighted in the study by Rasenack et al. (2002). For this reason, many compounds used in dietary supplements are micronised.

Unmissable formula properties

Diosmin Complex is packed with positive properties, not only due to the presence of Diosmin but also thanks to the accompanying extracts, standardised for significant nutrients.

Among the most notable effects of the formula are the properties of Vitamin C, which contribute to the normal function of the immune system and cell protection against oxidative damage.

Usage recommendations for Diosmin Complex

Two valid ways to use Diosmin Complex for athletes are:

•  Close to training sessions.
•  Away from training sessions.

This is why using Diosmin Complex close to training is common among athletes during periods of high training load, such as near a significant competition. However, as a general rule, it is recommended to use it at least 4 hours before or after training.

For non-athletes, the timing of use is not critical. You can use Diosmin Complex in the morning or evening.

Combine it for enhanced potency!

Popular combinations with Diosmin Complex include:

•  OPC Complex.
•  Red Beetroot Powder.
•  Coenzyme Q10.

References

•  Huwait, E., & Mobashir, M. (2022). Potential and Therapeutic Roles of Diosmin in Human Diseases. Biomedicines, 10(5).
•  Pastor, R., & Tur, J. A. (2019). Antioxidant Supplementation and Adaptive Response to Training: A Systematic Review. Current Pharmaceutical Design, 25(16), 1889–1912.
•  Lyseng-Williamson, K. A., & Perry, C. M. (2003). Micronised purified flavonoid fraction: a review of its use in chronic venous insufficiency, venous ulcers and haemorrhoids. Drugs, 63(1), 71–100.
•  Cazaubon, M., Benigni, J.-P., Steinbruch, M., Jabbour, V., & Gouhier-Kodas, C. (2021). Is There a Difference in the Clinical Efficacy of Diosmin and Micronized Purified Flavonoid Fraction for the Treatment of Chronic Venous Disorders? Review of Available Evidence. Vascular Health and Risk Management, 17, 591–600.
•  Serra, R., Ielapi, N., Bitonti, A., Candido, S., Fregola, S., Gallo, A., … Gallelli, L. (2021). Efficacy of a Low-Dose Diosmin Therapy on Improving Symptoms and Quality of Life in Patients with Chronic Venous Disease: Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients, 13(3).