DAOlytic: diamine oxidase for histamine
DAOlytic (Diamine Oxidase) 36288 HDU from EssentialSeries is a dietary supplement made with a protein extract from pork kidneys standardized to 7% diamine oxidase, also known as DAO. We developed this formula for those looking for a specific option within dietary supplementation, focused on a rather unusual enzyme, highly valuable and especially interesting for people paying attention to the histamine in their diet.
Histamine is a molecule naturally found in the body and also in many foods, especially those that have undergone maturation, fermentation, curing, or preservation processes. That’s why more and more people want to better understand what happens with dietary histamine and the role enzymes involved in its metabolism play. In this context, DAO stands out as a very specific enzyme, with a well-defined biological function and a technical evaluation based on enzymatic activity.
DAOlytic isn’t a generic formula: it’s a premium dietary supplement focused on a specific enzyme, with activity expressed in HDU and a carefully selected ingredient.
A clear and straightforward way to add diamine oxidase to your routine, especially when you want to pay more attention to histamine.
What is DAO and why is it talked about so much
DAO, or diamine oxidase, is an enzyme naturally present in our body, related to the transformation of histamine from food. To put it simply, we can imagine enzymes as tiny biological tools linked to specific reactions inside the body. Each enzyme has an affinity for certain compounds, and DAO is specifically associated with dietary histamine in the digestive environment.
This point is important because histamine doesn’t only appear in specific situations: it can be present in common foods like cured cheeses, cold cuts, fish, seafood, fermented foods, alcoholic drinks, canned goods, or foods subjected to long maturation processes.
At HSN, we wanted DAOlytic to be easy to understand even if you’ve never heard of DAO. You don’t need to know all the biochemical details to use it wisely: the key is knowing it’s a specialized enzyme, naturally present in your body and related to dietary histamine. It’s designed to be taken following the package instructions, before meals.
DAO isn’t a general digestive enzyme like those associated with proteins, fats, or carbohydrates. It’s a much more specific enzyme, linked to histamine.
36288 HDU: why enzymatic activity makes the difference
In an enzyme product, quality isn’t just about the “amount of ingredient” listed in the formula. It’s also crucial to know its enzymatic activity, meaning the declared functional capacity of that enzyme under controlled measurement conditions. That’s why in DAOlytic we highlight its 36288 HDU per capsule, a technical unit that helps express the activity of diamine oxidase in a more useful and understandable way.
HDU refers to activity units related to histamine. Simply put, it allows assessing DAO’s activity against its reference substrate, instead of just focusing on the extract’s weight. This is especially important in enzymatic ingredients because two products can provide similar raw material amounts but not offer the same declared activity.
That’s why DAOlytic is designed as a premium product: we don’t just say it contains DAO, but provide a formula with high activity, standardized ingredient, and a clear explanation so you know exactly what you’re adding to your routine.
When it comes to enzymes, activity matters. In DAOlytic, the 36288 HDU is a technical way to express the functional value of the diamine oxidase in the formula.
An exclusive ingredient standardized to 7% DAO
DAOlytic uses a protein extract from pork kidneys standardized to 7% diamine oxidase. We selected this type of ingredient because origin and extraction process are key factors in such a specific enzyme. Here, we’re talking about an animal-based raw material that meets a very specific technical criterion: providing DAO from a source recognized for its relevance in this category.
This 7% standardization lets us communicate the composition transparently. We’re not talking about an undefined extract or a mix without clarity, but a protein raw material with a declared DAO content and enzymatic activity expressed in HDU.
We’ve also considered that enzymes are sensitive ingredients. Their activity can depend on factors like raw material origin, extraction process, temperature, humidity, and storage conditions. That’s why, for a product like DAOlytic, proper storage is important to avoid conditions that could compromise ingredient stability.
- Protein extract from pork kidneys.
- Standardized to 7% diamine oxidase.
- 36288 HDU enzymatic activity per capsule.
- Specific formula for people interested in dietary histamine.
Who DAOlytic is for
DAOlytic fits especially well for people who have already started reviewing histamine presence in their diet, but also for those taking their first steps and looking for a supplement. It’s an interesting option for users who identify certain meals as more challenging in their diet, for those who frequently consume fermented, cured, or matured foods, or for those who prefer having a specific nutritional tool for particular moments.
It can also appeal to people who already know DAO and seek a quality formula with: declared enzymatic activity, ingredient origin, standardization, and clear composition. In these types of products, transparency is especially important because advanced users don’t just look for “a product with DAO,” but a formula that clearly explains what it offers and why that ingredient was chosen.
If you’re just starting, our recommendation is to see it as a specialized dietary supplement, not as a solution or substitute for an adapted diet. The foundation should always be a varied diet and a healthy lifestyle.
How to integrate DAOlytic into your routine
DAOlytic is designed to be used following the instructions on the package, 20 minutes before meals. Since it’s an enzyme, timing matters: it’s not a product to use anytime during the day, but a formula designed to accompany specific moments.
It’s a good option for people who plan certain meals more carefully, especially regarding dietary histamine.
How to combine DAOlytic
DAOlytic already has a very specific focus on its own, so it doesn’t necessarily need to be combined with other products. Still, it can be integrated into a broader routine if you’re looking for an organized dietary supplementation strategy tailored to your needs.
Why choose DAOlytic from HSN
At HSN, we designed DAOlytic as a premium product because DAO isn’t a common ingredient. It’s a specific enzyme, with a very technical positioning and a consumer who needs to clearly understand what they’re buying. That’s why we prioritized three aspects: a selected raw material, clearly declared enzymatic activity, and a simple explanation so the product is understandable both for advanced users and for people just discovering this field.
We didn’t want to build DAOlytic’s value around a long mix of ingredients, but around DAO’s own interest. A premium formula isn’t the one with the most ingredients, but the one that best selects the key ingredient, with transparency, and presents it in a practical, high-concentration format.
DAOlytic is a bet on specialization: a specific formula, with an exclusive ingredient and high enzymatic activity for those who seek DAO with good judgment.
Frequently asked questions
What does it mean that DAOlytic provides 36288 HDU?
HDU is a technical unit related to DAO’s enzymatic activity. In enzyme products, this data is especially important because it allows assessing the ingredient’s activity, not just its weight. That’s why the 36288 HDU in DAOlytic is one of the formula’s key elements.
Is DAOlytic a general enzyme?
No. DAOlytic isn’t designed as a mix of general enzymes for proteins, fats, or carbohydrates. Its focus is more specific: it provides diamine oxidase, an enzyme linked to processes related to dietary histamine.
Is DAOlytic vegan?
No. DAOlytic contains a protein extract from pork kidneys standardized to 7% diamine oxidase, so it’s not suitable for vegans or vegetarians or for those avoiding pork-derived ingredients for cultural or religious reasons.
When should DAOlytic be taken?
It should always be taken following the package instructions. Due to its enzymatic nature, it’s designed to be used in relation to specific meals, especially within dietary routines paying attention to histamine from food.
Does it replace a low-histamine diet?
No. DAOlytic is a dietary supplement and not a substitute for an adapted diet, professional guidance, or individual assessment. It can be part of a planned routine, but diet and personalized follow-up remain essential when there’s a specific need.
Is it a product suitable for beginners?
Yes. DAOlytic is a premium product, but its use is simple: it’s designed for people who want to add DAO to their routine practically and with a clear formula. If it’s your first time using a product like this, we recommend reading information about DAO and its application.
DAOlytic: a premium formula based on DAO
DAOlytic (Diamine Oxidase) 36288 HDU is our proposal for those looking for a specialized dietary supplement focused on DAO with clear activity. We selected a protein extract from pork kidneys standardized to 7% DAO to offer a formula with high technical value, easy to understand, and designed to accompany specific meals within a conscious dietary routine.
It’s an option for those who want to take a step further in caring for their diet, better understand dietary histamine, and choose an exclusive product with the transparency and judgment that characterize HSN.
References
- Costa-Català, J., Pellicer-Roca, S., Iduriaga-Platero, I., Sánchez-Pérez, S., Veciana-Nogués, M. T., Latorre-Moratalla, M. L., Vidal-Carou, M. C., & Comas-Basté, O. (2024). Impact of technological factors on diamine oxidase (DAO) activity in porcine kidney extracts as active ingredient for the dietary management of histamine intolerance. Applied Food Research, 4(2), 100592.
- Sánchez-Pérez, S., Comas-Basté, O., Costa-Català, J., Iduriaga-Platero, I., Veciana-Nogués, M. T., Vidal-Carou, M. C., & Latorre-Moratalla, M. L. (2022). The rate of histamine degradation by diamine oxidase is compromised by other biogenic amines. Frontiers in Nutrition, 9, 897028.
- Schnedl, W. J., Schenk, M., Lackner, S., Enko, D., Mangge, H., & Forster, F. (2019). Diamine oxidase supplementation improves symptoms in patients with histamine intolerance. Food Science and Biotechnology, 28, 1779-1784.
- Izquierdo-Casas, J., Comas-Basté, O., Latorre-Moratalla, M. L., Lorente-Gascón, M., Duelo, A., Soler-Singla, L., & Vidal-Carou, M. C. (2019). Diamine oxidase (DAO) supplement reduces headache in episodic migraine patients with DAO deficiency: A randomized double-blind trial. Clinical Nutrition, 38(1), 152-158.
