SAMe 200mg - Purity, stability, and technical excellence
SAMe 200mg from EssentialSeries is a dietary supplement based on S-adenosyl-L-methionine.
In delayed-release vegetable capsules, formulated with Microencapsulated S-Adenosyl-L-Methionine Disulfate Tosylate. It’s an advanced formula that combines stability, purity, and top quality. Developed with a quality-focused approach, our SAMe 200mg strikes the perfect balance between scientific innovation and the commitment that has made us an international benchmark in dietary supplements and healthy nutrition. The choice of its form is no accident: we picked disulfate tosylate because it’s a salt known for greater stability compared to the free form, able to resist oxidation and keep its structure intact.
One capsule a day is enough to get a quality source of the exclusive compound: S-Adenosyl-L-Methionine.
Why choose our SAMe?
Stability that makes a difference
SAMe is a molecule sensitive to factors like temperature, light, or humidity. That’s why the stability of its chemical form is crucial. Our choice of Disulfate Tosylate ensures optimal preservation of the compound. It’s the form used in scientific studies for its ability to withstand varying environmental conditions without losing quality.
New! - Advanced microencapsulation: total protection
Using microencapsulation technology, each SAMe particle is coated with a thin protective layer that acts as a shield against light, oxygen, and moisture. This layer prevents compound degradation (as an extra protection system alongside disulfate tosylate) and allows for more controlled release in the intestine, where SAMe absorption takes place.
New delayed-release capsule
The delayed-release system of our capsules prevents SAMe exposure to the stomach’s acidic pH, ensuring it arrives intact at the intestinal absorption sites. This optimizes the compound’s actual availability and avoids losses linked to gastric acidity, a remarkable advance considering how sensitive the compound is.
At HSN we’re committed to technological innovation, guaranteeing quality, stability, and practical use.
Clean label philosophy - what does it mean?
Our approach to formulating SAMe 200mg is based on a clear principle: only offer what’s necessary. No colorants, no preservatives, no unnecessary additives or aesthetics... Basically, stuff you don’t need. Every ingredient serves a clear purpose and is used for its relevance, ensuring a conscious and quality dietary supplement experience.
Commitment to quality - key in SAMe
From raw material reception to the product arriving at your door, at HSN we focus our efforts on guaranteeing the highest standard of analytical controls that certify purity and quality, which is especially crucial for sensitive compounds like SAMe.
S-Adenosyl-L-Methionine, what is it?
SAMe is a natural molecule present in the body, synthesized from the amino acid methionine and ATP. Its biological role has been widely studied due to its involvement in various cellular processes. As a dietary supplement, its interest lies in its structural complexity and relevance in fundamental metabolic pathways.
Selection of the most stable form
There are several SAMe salts, but Disulfate Tosylate is considered the reference form for its durability and nutritional behavior. This format keeps SAMe intact, preserving its properties and preventing degradation reactions when exposed to environmental moisture or oxidation, a key aspect for proper product preservation.
Suitable for vegan diets
The vegetable capsules we use for our SAMe 200mg are made from hydroxypropyl methylcellulose, a material derived from natural plant sources. The entire microencapsulation and production process of SAMe is compatible with vegan diets, with no gelatin or animal-derived ingredients.
Absolute transparency - HSN hallmark
Our mindset regarding product information is clear: communicate every detail in an understandable and easy-to-grasp way. That’s why our SAMe 200mg shows its composition fully. No proprietary blends, with clear breakdowns of how much tosylate, SAMe itself, and even methionine each capsule provides. All info is displayed legibly and simply on the label, and you can also find it on the 'NUTRITION INFO' tab of this page. What you see is exactly what you get.
In a market flooded with confusing formulas, our bet is to offer a clear product, with the highest quality formulation and development, and no unnecessary additives. SAMe 200mg proves that transparency, science backing, and quality are the best choice when buying your dietary supplements.
Additional recommendations about SAMe
- It’s better to take it on an empty stomach, as absorption is more effective.
- No refrigeration needed, even if you read otherwise on other sites, SAMe with protective systems like ours doesn’t benefit from cold storage. Just keep it in a cool, dry place away from direct light.
- Thanks to its stable and microencapsulated form, the product comfortably retains its properties, so you don’t need to buy small formats to renew your supply frequently; even larger presentations keep their full potential when stored properly.
Frequently asked questions
What does it mean that SAMe is “microencapsulated”?
It means the nutrient is protected inside a microscopic matrix that isolates it from external factors, improving its preservation and long-term stability. This process prevents compound degradation and enhances its resistance over time.
Is the microencapsulation made with dairy like other cases I’ve seen?
No. The entire product is made from plant-based raw materials and is allergen-free.
What’s the difference between SAMe and methionine?
The difference lies in molecular complexity: SAMe is a molecule synthesized from methionine that performs different functions in human metabolism. Our formulation presents the compound directly in its stable and bioavailable form (disulfate tosylate).
SAMe or NAC? Which one should I choose?
Although both compounds are related to similar biological properties, they are not equivalent nor used for the same purposes. S-Adenosyl-L-Methionine (SAMe) is a compound generated from methionine and ATP, while N-Acetylcysteine (NAC) is a derivative of the amino acid cysteine. Each has its own characteristics regarding structure and nutritional applications, so the choice depends on individual context.
Bibliography to learn more
- Bottiglieri, T. (2002). S-Adenosyl-L-methionine (SAMe): From the bench to the bedside - Molecular basis of a pleiotrophic molecule. American Journal of Clinical Nutrition, 76(5), 1151S-1157S.
- Lu S. C. (2000). S-Adenosylmethionine. The international journal of biochemistry & cell biology, 32(4), 391–395.
- Baden, K. E. R., McClain, H., Craig, E., Gibson, N., Draime, J. A., & Chen, A. M. H. (2024). S-Adenosylmethionine (SAMe) for Central Nervous System Health: A Systematic Review. Nutrients, 16(18), 3148.
- Friedel, H. A., Goa, K. L., & Benfield, P. (1989). S-adenosyl-L-methionine. A review of its pharmacological properties and therapeutic potential in liver dysfunction and affective disorders in relation to its physiological role in cell metabolism. Drugs, 38(3), 389–416.
- Limveeraprajak, N., Nakhawatchana, S., Visukamol, A., Siripakkaphant, C., Suttajit, S., & Srisurapanont, M. (2024). Efficacy and acceptability of S-adenosyl-L-methionine (SAMe) for depressed patients: A systematic review and meta- analysis. Progress in neuro-psychopharmacology & biological psychiatry, 132, 110985.
- Sales, A. J., Maciel, I. S., Crestani, C. C., Guimarães, F. S., & Joca, S. R. (2023). S-adenosyl-l-methionine antidepressant-like effects involve activation of 5-HT1A receptors. Neurochemistry international, 162, 105442.
- Lieber C. S. (2002). S-adenosyl-L-methionine: its role in the treatment of liver disorders. The American journal of clinical nutrition, 76(5), 1183S–7S.
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